Astrocytes Resist HIV-1 Fusion but Engulf Infected Macrophage Material

Astrocytes Resist HIV-1 Fusion but Engulf Infected Macrophage Material

HIV-1 disseminates to diverse tissues and establishes long-lived viral reservoirs. These reservoirs include the CNS, in which macrophage-lineage cells, and as suggested by many studies, astrocytes, may be infected. Here, we have investigated astrocyte infection by HIV-1. We confirm that astrocytes trap and internalize HIV-1 particles for subsequent release but find no evidence that these partic...

HIV-1-Infected Macrophage Giant Cells Cytoskeletal Protein Transformation in

HIV-1 Membrane Fusion

The AIDS pandemic is spreading unchecked in many parts of the world. Currently available anti-viral regimens are plagued by their high cost, by serious side effects in a significant minority of recipients, and by the increasing problems of drug-resistant HIV variants. Fortunately, rapid advances in understanding how HIV-1 enters cells have lead to the identification of promising new drug target...

HIV-1 and the macrophage

Future Virol. (2011) 6(2), 187–208 10.2217/FVL.10.93 © 2011 Future Medicine Ltd HIV-1-infected monocytes and macrophages play crucial roles in establishing the viral reservoir and in the etiology of multiple HIV-1-associated pathologies. In this article, we discuss current knowledge on HIV-1 replication in monocytes and macrophages, with emphasis on macrophage polarization/activation and associ...

Intercellular Adhesion Molecule 1 Promotes HIV-1 Attachment but Not Fusion to Target Cells

Incorporation of intercellular adhesion molecule 1 (ICAM-1) into HIV-1 particles is known to markedly enhance the virus binding and infection of cells expressing lymphocyte function-associated antigen-1 (LFA-1). At the same time, ICAM-1 has been reported to exert a less pronounced effect on HIV-1 fusion with lymphoid cells. Here we examined the role of ICAM-1/LFA-1 interactions in productive HI...